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ANSWER
1
(b) Benzyl alcohol is classified as a preservative. Preservatives
prevent the growth of microorganisms and prevent deterioration of
pharmaceutical dosage forms. The ideal preservative must have the
following characteristics:
It
must be effective against a broad spectrum of microorganisms. It
must be stable for the lifetime of the product. It must be nontoxic,
soluble, palatable in test and odor and compatible with other
ingredients in the formulation.
Commonly
used preservatives:
*
phenol * benzoic acid
* benzyl alcohol * chlorobutanol
* thiomersal * benzalkonium
* cresol * cetylpyridinium
ANSWER
2
(c) Cold cream is an example of W/O emulsion. It is a biphasic
liquid dosage form, in which disperse phase and the dispersion
medium are liquids. Emulsion is classified by five different
categories:
Water
in Oil (W/O) : Oil is continuous phase and water is a disperse
phase, i.e. lotions and liniments.
Oil
in water (O/W) : Water is continuous phase and oil is a dispersed
phase i.e. most of the oral emulsions to unmask the oil taste of a
medication.
Microemulsion
: Unlike emulsions, microemulsion is a transparent with a small
particle size. It is believed to be thermodynamically stable. The
particle size of microemulsion lies between 10 to 200 nm. It is
generally used for the solubilization of the drug in pharmaceutical
dosage form.
Nanoparticles
: As the name suggests, the particle size of this kind of emulsion
is limited to nanograms. They are useful for the preparation of
globulins and toxoids. Tetanus toxoid and human immunoglobulin G are
examples of nanoparticles emulsion.
Multiple
emulsions : Water in Oil in ware (W/O/W), Oil in water in Oil
(O/W/O). The w/o/w emulsions are generally more preferable for
preparation of various pharmaceutical dosage forms. They are used to
prolong the duration of action of various drugs, to localize drug in
the body and to prepare cosmetics.
ANSWER
3
(b) Sucrose is an example of Oligosaccharide. It consists of a short
chain of monosaccharide. It consists of one molecule of glucose and
one molecule of fructose.Carbohydrates can be divided into three
categories : Monosaccharide, Oligosaccharide and Polysaccharide.
Monosaccharides
: They are simple sugar such as glucose and fructose.
Oligosaccharides
: Consists of a small chain of monosaccharides. i.e. sucrose,
maltose and lactose. They have to degraded into simple sugar in
order to be absorb from the intestine. Degradation of sucrose gives
one molecule of glucose and fructose, degradation of maltose gives
two molecules of glucose, and degradation of lactose gives each
molecule of galactose and glucose.
Polysaccharides
: They consist of long chains of monosaccharides i.e. starch and
glycogen
ANSWER
4
(c) Uracil. It is a pyrimidine base that only found on RNA.
Nucleotides
are the building blocks of the nucleic acid. Purines and pyrimidines
bases bind to ribose to form nucleoside, which when binded to
phosphoric acid forms the nucleotides.
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